ONCC TCTCN Certification Exam Syllabus

ONCC TCTCN syllabus for ONCC Transplantation and Cellular Therapy Certified Nurse (TCTCN) preparation

Welcome to the official MedicoExam syllabus guide for the ONCC Transplantation and Cellular Therapy Certified Nurse certification. This page delivers a clear, structured overview of the ONCC TCTCN exam, including key exam details, syllabus topics, and preparation references to support effective study planning. The ONCC Transplantation and Cellular Therapy Certified Nurse (TCTCN) is intended for professionals pursuing roles aligned with Nursing Certification, with assessment centered on applied competencies such as HSCT and cellular therapy foundations and administration, post-HSCT and post-cellular therapy management, quality-of-life and professional practice competencies within real-world settings like hematopoietic stem cell transplantation programs, cellular therapy programs, hematology/oncology care settings.

The syllabus outline below reflects the core domains and expectations defined by the official ONCC certification framework and aligns with the cognitive and professional standards assessed in the ONCC TCTCN exam. Candidates can use this guide alongside official vendor resources and structured practice to align their preparation with current exam standards and professional expectations for Transplantation and cellular therapy registered nurses, oncology registered nurses, nursing administrators/educators/researchers in transplantation and cellular therapy

ONCC TCTCN Exam Summary and Key Details

Exam Name	ONCC Transplantation and Cellular Therapy Certified Nurse
Credential	ONCC Transplantation and Cellular Therapy Certified Nurse (TCTCN)
Vendor	Oncology Nursing Certification Corporation (ONCC)
Exam Code	TCTCN » ONCC TCTCN Certification Practice Exam
Exam Delivery Mode	Computer-based testing at PSI test centers
Exam Duration	180 mins
Number of Questions	165 (125 scored and 40 unscored)
Passing Score	55 on a scale of 25-75
Exam Price	ONS/APHON Member - $300 Nonmember - $420
Scheduling Window	90 days from issuance of the Authorization to Test (ATT)
Schedule Exam	ONCC
Trainings/Resources	2026 TCTCN™ Test References
Sample Questions	ONCC TCTCN Exam Sample Questions
Recommended Practice	ONCC TCTCN Certification Practice Exam

ONCC TCTCN Exam Syllabus Topics and Weighting

Topic Areas	Topic Details, Courses, Books	Weighting
Foundations of HSCT and Cellular Therapy	- Basic concepts of HSCT and cellular therapy Hematopoietic cell lineage and function Immune system and function Histocompatibility (e.g., HLA typing) - Goals of therapy (e.g., graft-versus-tumor effect, hematologic/immune reconstitution, immunotherapy) - Indications for HSCT or cellular therapy (e.g., malignant, non-malignant, immune system disorders) - Types of HSCT and cellular therapy Autologous Allogeneic Cellular therapy - Sources of cells Peripheral blood Bone marrow Umbilical cord Tumor - Recipient suitability and evaluation - Recipient education - Caregiver education - Donor selection, care, and education	22%
HSCT and Cellular Therapy Process and Administration	- Cellular therapy product collection and storage - HSCT product mobilization, collection, harvest, and storage - Conditioning / preparative regimens Intensity of therapy Chemotherapy Radiation therapy (e.g., TBI, fractionated) Biotherapy Immunotherapy Targeted therapies - Management of acute complications related to preparative regimens - Product administration Fresh vs. cryopreserved Infusion and injection management Hematologic compatibilities	22%
Post-HSCT Management and Education	- Early Post-HSCT Management and Education Immunosuppressive therapy aGVHD Infection prevention and management Sepsis Hematologic (e.g., engraftment, pancytopenia, transfusion support) Immune (e.g., engraftment syndrome, cytokine release syndrome, Hemophagocytic lymphohistiocytosis) Acute system specific complications (e.g., Sinusoidal obstructive syndrome, gastrointestinal) Graft rejection or failure Chimerism Symptom management for alterations in physiologic function (e.g., pain, nausea, vomiting, fatigue, nutrition support, mobility) - Late Post-HSCT Management and Education cGVHD (e.g., medical management, photopheresis) System-specific late effects (e.g., bronchiolitis obliterans syndrome, cataracts, infertility, cognitive deficits) Infection prevention and management (e.g., immunizations, antimicrobial prophylaxis) Disease relapse Subsequent malignancy Follow-up care and milestone visits	22%
Post-Cellular Therapy Management and Education	- Early Post-Cellular Therapy Management and Education Infection prevention and management Sepsis Hematologic (e.g., pancytopenia, transfusion support) Immune (e.g., neurotoxicity, cytokine release syndrome, Hemophagocytic lymphohistiocytosis) Symptom management for alterations in physiologic function (e.g., pain, nausea, vomiting, fatigue, nutrition support, mobility) Treatment failure (e.g., disease progression, disease relapse) - Late Post-Cellular Therapy Management and Education System-specific late effects (e.g., neurotoxicity, pancytopenia, hypogammaglobulinemia) Infection prevention and management (e.g., immunizations, antimicrobial prophylaxis) Disease relapse Subsequent malignancy Follow-up care and milestone visits	22%
Quality of Life	- Navigation and coordination throughout the continuum - Psychosocial (e.g., coping, family, and caregiver support) - Health promotion and maintenance - Sexuality - Cultural and spiritual competence - Survivorship - Palliative care -End-of-life care (e.g., hospice, legacy building)	8%
Professional Performance	- HSCT and cellular therapy standards of professional performance: Nursing scope of practice Evidence-based practice, research, and quality improvement Communication and interprofessional collaboration Professional development Environmental health and safety (e.g., personal protective equipment, safe handling) - Ethical and legal considerations (e.g., informed consent, advance directives, professional boundaries, patient, and donor advocacy) - Accreditation (e.g., FACT, The Joint Commission, REMS) - Self-care	4%

The ONCC TCTCN certification exam is designed to assess both theoretical knowledge and applied professional judgment in Nursing Certification. The exam evaluates competencies such as HSCT and cellular therapy foundations and administration, post-HSCT and post-cellular therapy management, quality-of-life and professional practice competencies, ensuring candidates are prepared for real-world responsibilities as Transplantation and cellular therapy registered nurses, oncology registered nurses, nursing administrators/educators/researchers in transplantation and cellular therapy working in settings such as hematopoietic stem cell transplantation programs, cellular therapy programs, hematology/oncology care settings.

To prepare effectively for the ONCC Transplantation and Cellular Therapy Certified Nurse exam, candidates are encouraged to review official vendor materials, complete structured practice assessments, and gain hands-on experience relevant to their professional role.