ONCC CPHON Certification Exam Syllabus

ONCC CPHON syllabus for ONCC Certified Pediatric Hematology Oncology Nurse (CPHON) preparation

Welcome to the official MedicoExam syllabus guide for the ONCC Certified Pediatric Hematology Oncology Nurse certification. This page delivers a clear, structured overview of the ONCC CPHON exam, including key exam details, syllabus topics, and preparation references to support effective study planning. The ONCC Certified Pediatric Hematology Oncology Nurse (CPHON) is intended for professionals pursuing roles aligned with Nursing Certification, with assessment centered on applied competencies such as Symptom management and supportive care, treatment modalities and side effects, pediatric hematologic and oncologic emergency management within real-world settings like Pediatric hematology/oncology clinical settings, nursing education and administration settings, research and consultation settings.

The syllabus outline below reflects the core domains and expectations defined by the official ONCC certification framework and aligns with the cognitive and professional standards assessed in the ONCC CPHON exam. Candidates can use this guide alongside official vendor resources and structured practice to align their preparation with current exam standards and professional expectations for Pediatric hematology/oncology registered nurses, nursing administrators and educators, nursing researchers and consultants

ONCC CPHON Exam Summary and Key Details

Exam Name	ONCC Certified Pediatric Hematology Oncology Nurse
Credential	ONCC Certified Pediatric Hematology Oncology Nurse (CPHON)
Vendor	Oncology Nursing Certification Corporation (ONCC)
Exam Code	CPHON » ONCC CPHON Certification Practice Exam
Exam Delivery Mode	Computer-based testing at PSI test centers; year-round in the U.S., its territories, and Canada, with a limited annual international testing period
Exam Duration	180 mins
Number of Questions	165 (125 scored and 40 unscored)
Passing Score	55 on a scale of 25-75
Exam Price	ONS/APHON Member - $300 Nonmember - $420
Scheduling Window	90-day testing window beginning with the Authorization to Test (ATT); ATT is generally issued within 4–6 weeks after application
Schedule Exam	ONCC
Trainings/Resources	2026 CPHON® Test References
Sample Questions	ONCC CPHON Exam Sample Questions
Recommended Practice	ONCC CPHON Certification Practice Exam

ONCC CPHON Exam Syllabus Topics and Weighting

Topic Areas	Topic Details, Courses, Books	Weighting
Care Continuum	- Transition of care Primary care Levels of care (e.g., rehabilitation, home, outpatient) End-of-life care - Health promotion and maintenance - Survivorship	6%
Pediatric Hematology and Oncology Nursing Practice	- Pediatric cancers and hematologic disorders Clinical presentation Anatomy, physiology, and pathophysiology Genetics (including genomics) Diagnostic testing Diagnosis and prognosis - Clinical trials Phases Informed consent - Professional performance Scope and standards of nursing practice Patient and family education Ethical principles and practice Professional practice guidelines Regulatory standards and guidelines	18%
Treatment Modalities and Side Effects	- Hematology Chemotherapy Biotherapy Immunotherapy Blood product therapy Hematopoietic stem cell transplantation Surgery Coagulation therapy - Oncology Chemotherapy Biotherapy Immunotherapy Blood product therapy (e.g., leukapharesis) Cellular therapies (e.g., CAR-T) Radiation therapy (e.g., I-131-MIBG, proton beam radiation) Hematopoietic stem cell transplantation Surgery	21%
Symptom Management and Supportive Care	- System-specific acute, chronic, and late effects Neurological Respiratory Cardiovascular Gastrointestinal Renal/genitourinary Musculoskeletal Integumentary Endocrine Reproductive Hematological Immunological Ophthalmological Otological (Auditory) Lymphatic - General acute, chronic, and late effects Pain Sleep disturbance Fatigue Mental health - Supportive care Medical devices (e.g., venous access, pumps, shunts, tubes) Blood product administration Colony-stimulating factors Interdisciplinary care Palliative care Complementary and integrative modalities	26%
Pediatric Hematologic and Oncologic Emergencies	- Infection Sepsis Typhlitis - Gastrointestinal Pancreatitis Bowel obstruction - Metabolic Diabetes insipidus Syndrome of inappropriate antidiuretic hormone Tumor lysis syndrome Cytokine release syndrome - Vascular Disseminated intravascular coagulation Hemorrhage Hyperleukocytosis Sinusoidal obstructive syndrome (veno-occlusive disease) Splenic sequestration Vaso-occlusive crisis Stroke Joint bleed (e.g., hemophilia) Thrombosis - Cardiopulmonary Acute chest syndrome Respiratory distress (e.g., mediastinal mass) Pleural effusions Arrhythmias - Neurology Increased intracranial pressure Seizures Posterior reversible encephalopathy syndrome (PRES) Spinal cord compression - Hypersensitivity reactions - Extravasation	21%
Psychosocial Dimensions of Care	- Social relationships and family dynamics Effects of acute and chronic illness on the patient and family Patient and family/caregiver support Integration of patient care into family, school, work, camp, and social environment - Principles of growth and development - Grief and bereavement - Cultural considerations and diversity - Sexuality and gender identity - Socioeconomic issues - Community resources	8%

The ONCC CPHON certification exam is designed to assess both theoretical knowledge and applied professional judgment in Nursing Certification. The exam evaluates competencies such as Symptom management and supportive care, treatment modalities and side effects, pediatric hematologic and oncologic emergency management, ensuring candidates are prepared for real-world responsibilities as Pediatric hematology/oncology registered nurses, nursing administrators and educators, nursing researchers and consultants working in settings such as Pediatric hematology/oncology clinical settings, nursing education and administration settings, research and consultation settings.

To prepare effectively for the ONCC Certified Pediatric Hematology Oncology Nurse exam, candidates are encouraged to review official vendor materials, complete structured practice assessments, and gain hands-on experience relevant to their professional role.