
The ACRP Certified Principal Investigator Certification Sample Question Set on this page is designed to familiarize you with the actual ACRP CPI exam format and question types. These sample questions help you understand how questions are structured and what to expect on test day. While they provide a useful starting point, they represent only a limited preview of the real exam experience.
These sample questions are intended for evaluation and familiarization only. To understand exam style, pacing, and reasoning patterns more clearly, we recommend trying our online sample practice environment. If you are preparing for the ACRP Certified Principal Investigator (CPI) and want to assess your readiness more rigorously, structured, timed, scenario-based practice is recommended. This approach aligns with the cognitive demands and professional expectations typically associated with principal investigators, sub-investigators, clinical investigators and related roles working in settings such as clinical trial sites, academic medical centers, research hospitals and institutions.
...





The ACRP Certified Principal Investigator Exam, identified as CPI, is administered by the Association of Clinical Research Professionals. It evaluates whether principal investigators and sub-investigators can apply research-design principles, protect participant safety and rights, maintain regulatory and protocol compliance, oversee trial operations, manage study sites, and ensure accurate clinical research data.